Sephure Suppository Applicator: Sephure is a disposable, single-use suppository applicator that enables patients to quickly, hygienically and comfortably administer rectal suppositories. Cannabis suppositories provide superior bio-availability with an efficiency rate of 50-70%, compared to edibles that may only provide 20% absorption. Onset: 10-15 minutes. Duration: 4-8 hours. Ingredients: Organic coconut oil, organic beeswax, organic cocoa butter, cannabis oil. Instructions